In cells throughout the body, tumor suppressor genes include DAXX, ATRX and MEN1. These genes help control how cells read and use their DNA. They act like “managers” that keep cell growth organized and help prevent cells from growing out of control.
Mutations or loss of these genes are common in pancreatic neuroendocrine tumors (pNETS). The absence of DAXX or ATRX can also indicate a more aggressive tumor and poorer prognosis.
Biopsies on solid tumors can help determine if you have a mutation or loss of these tumor suppressor genes.
Loss of these tumor suppressors in pancreatic neuroendocrine cancers (pNET) may help identify clinical trials that are investigating effective therapies.
